郭余民（Yu-Min Kuo, Ph.D.）

細胞生物與解剖學研究所  教授    分機：5294      Email: kuoym@mail.ncku.edu.tw

研究興趣：

1. Exploring the pathophysiology of Alzheimer’s disease and seeking effective treatment approaches
2. Mechanisms by which metabolic disorders contribute to the development of depression
3. Understanding how exercise counteracts Alzheimer’s disease and depression, as well as modulating the autonomic nervous system

近五年代表作：

1. Chang CW, Hsu JY, Lo YT, Liu YH, Mee-Inta O, Lee HT, Kuo YM*, Liao PC*. (2024 Feb) Characterization of hair metabolome in 5xFAD mice and patients with Alzheimer’s disease using mass spectrometry-based metabolomics. ACS Chemical Neuroscience 15(3):527-538.
2. Hung HC, Tsai SF, Chou HW, Tsai MJ, Hsu PL*, Kuo YM*. (2023 Apr) Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes. Scientific Reports 13:5511.
3. Mee-Inta O, Hsieh CF, Chen DQ, Fan CH, Chiang YY, Liu CC, Sze CI, Gean PW, Wu PC, Yang MS, Huang PS, Wu PC, Kuo YM*, Huang CC*. (2023 Feb) High-frequency ultrasound imaging for monitoring the function of meningeal lymphatic system in mice. Ultrasonics 131:106949.
4. Tsai SF, Hsu PL, Chen YW, Hossain MS, Chen PC, Tzeng SF, Chen PS, Kuo YM*. (2022 Nov) High-fat diet induces depression via astrocyte-mediated hyperactivation of the ventral hippocampal glutamatergic afferents to the nucleus accumbens. Molecular Psychiatry 27: 4372-4384.
5. Tsai SF, Hung HC, Shih MC, Chang FC, Chung BC, Wang CY, Lin YL, Kuo YM*. (2022 Jan) High-fat diet-induced increases in glucocorticoids contribute to the development of non-alcoholic fatty liver disease in mice. FASEB Journal 36: e22130.
6. Wang TF, Tsai SF, Zhao ZW, Kuo YM*. (2021 Aug) Exercise-induced increase of corticosterone participates in exercise-enhanced adult hippocampal neurogenesis in mice. Chinese Journal of Physiology, 64: 186-193.
7. Lkhagvasuren B, Mee-inta O, Zhao ZW, Hiramoto T, Boldbaatar D, Kuo YM*. (2021 Jul) Pancreas-brain crosstalk. Frontiers in Neuroanatomy 15:691777.
8. Wu SY, Pan BS, Tsai SF, Chiang YT, Huang BM, Mo FE, Kuo YM*. (2020 Jul) BDNF reverses aging-related microglial activation. Journal of Neuroinflammation 17:210.
9. Tsai SF, Liu YW, Kuo YM*. (2019 Nov) Acute and long-term treadmill running differentially induce c-Fos expression in regions- and time-dependent manners in mouse brain. Brain Structure & Function 224, 2677-2689.
10. Mee-inta O, Zhao ZW, Kuo YM*. (2019 Jul) Physical exercise inhibits inflammation and microglial activation. Cells 8, 691.